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IMPDH2-IN-2
CAS No. 1434517-02-8
IMPDH2-IN-2( —— )
Catalog No. M35632 CAS No. 1434517-02-8
IMPDH2-IN-2 is a potent inhibitor of inosine 5'-monophosphate dehydrogenase (IMPDH) (Ki,app: 14 μM) and a potential anti-tuberculosis agent, exhibiting moderate antibacterial effects with MIC values of 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 152 | Get Quote |
|
| 5MG | 235 | Get Quote |
|
| 10MG | 376 | Get Quote |
|
| 25MG | 730 | Get Quote |
|
| 50MG | 1224 | Get Quote |
|
| 100MG | 1935 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameIMPDH2-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionIMPDH2-IN-2 is a potent inhibitor of inosine 5'-monophosphate dehydrogenase (IMPDH) (Ki,app: 14 μM) and a potential anti-tuberculosis agent, exhibiting moderate antibacterial effects with MIC values of 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively.
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DescriptionIMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorDehydrogenase | Antibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number1434517-02-8
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Formula Weight428.27
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Molecular FormulaC21H15Cl2N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C([C@@H](OC1=C(Cl)C(Cl)=CC=C1)C)=O)C=2C=C3C(OC(=N3)C=4C=CN=CC4)=CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chacko S, et al. Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents [published correction appears in J Med Chem. 2021 Dec 23;64(24):18233-18234]. J Med Chem. 2018;61(11):4739-4756.?
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