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ABBV-318
CAS No. 1802848-94-7
ABBV-318( —— )
Catalog No. M35612 CAS No. 1802848-94-7
ABBV-318 can be used as small molecule Nav1.7/Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 μM for hNav1.7 and 3.8 μM for hNav1.8. ABBV-318 can be used to study pain-related disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 90 | Get Quote |
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| 5MG | 136 | Get Quote |
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| 10MG | 217 | Get Quote |
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| 25MG | 426 | Get Quote |
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| 50MG | 685 | Get Quote |
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| 100MG | 1062 | Get Quote |
|
| 200MG | 1458 | Get Quote |
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| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameABBV-318
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NoteResearch use only, not for human use.
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Brief DescriptionABBV-318 can be used as small molecule Nav1.7/Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 μM for hNav1.7 and 3.8 μM for hNav1.8. ABBV-318 can be used to study pain-related disorders.
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DescriptionABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorOthers | Sodium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1802848-94-7
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Formula Weight405.35
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Molecular FormulaC20H15F4N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 166.67 mg/mL (411.18 mM; Ultrasonic )
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SMILESF[C@@H]1CCN(C1)C(=O)c1ccc2cc(Oc3ccc(cn3)C(F)(F)F)ccc2n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Patel MV, et, al. Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain. Bioorg Med Chem. 2022 Jun 1;63:11674?
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