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AChE/BChE-IN-10
CAS No. 2924824-48-4
AChE/BChE-IN-10( —— )
Catalog No. M35609 CAS No. 2924824-48-4
AChE/BChE-IN-10 is a potent dual inhibitor of AChE and BChE with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 exhibits good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 47 | In Stock |
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| 5MG | 35 | In Stock |
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| 10MG | 59 | In Stock |
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| 25MG | 122 | In Stock |
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| 50MG | 184 | In Stock |
|
| 100MG | 300 | In Stock |
|
| 200MG | 445 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAChE/BChE-IN-10
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NoteResearch use only, not for human use.
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Brief DescriptionAChE/BChE-IN-10 is a potent dual inhibitor of AChE and BChE with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 exhibits good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation.
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DescriptionAChE/BChE-IN-10 (Compound 7b) is a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 shows good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation and be used in Alzheimer’s disease (AD) research.
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In VitroAChE/BChE-IN-10 inhibits AChE in a non-competitive manner with Ki of 0.21 μM, and BChE in a mixed-fashion with Ki of 0.15 μM.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetAChE
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RecptorAChE | AChR
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Research Area——
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Indication——
Chemical Information
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CAS Number2924824-48-4
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Formula Weight402.53
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Molecular FormulaC26H30N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (62.11 mM; Ultrasonic (<60°C)
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SMILESO=C(NCCC1CCN(CC=2C=CC=CC2)CC1)C3=CC=C4C=C(OC)C=CC4=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mohd Abdullaha, et al. Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. Eur J Med Chem. 2020 Dec 1;207:112761.?
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