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AChE/BChE-IN-10

CAS No. 2924824-48-4

AChE/BChE-IN-10( —— )

Catalog No. M35609 CAS No. 2924824-48-4

AChE/BChE-IN-10 is a potent dual inhibitor of AChE and BChE with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 exhibits good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AChE/BChE-IN-10
  • Note
    Research use only, not for human use.
  • Brief Description
    AChE/BChE-IN-10 is a potent dual inhibitor of AChE and BChE with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 exhibits good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation.
  • Description
    AChE/BChE-IN-10 (Compound 7b) is a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 shows good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation and be used in Alzheimer’s disease (AD) research.
  • In Vitro
    AChE/BChE-IN-10 inhibits AChE in a non-competitive manner with Ki of 0.21 μM, and BChE in a mixed-fashion with Ki of 0.15 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    AChE
  • Recptor
    AChE | AChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2924824-48-4
  • Formula Weight
    402.53
  • Molecular Formula
    C26H30N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (62.11 mM; Ultrasonic (<60°C)
  • SMILES
    O=C(NCCC1CCN(CC=2C=CC=CC2)CC1)C3=CC=C4C=C(OC)C=CC4=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mohd Abdullaha, et al. Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. Eur J Med Chem. 2020 Dec 1;207:112761.?
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