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MK-0159
CAS No. 2641484-61-7
MK-0159( —— )
Catalog No. M35606 CAS No. 2641484-61-7
MK-0159 is an orally available, highly potent CD38 inhibitor with myocardial injury protection for the study of cardiac ischemia and reperfusion injury.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 117 | Get Quote |
|
| 10MG | 170 | Get Quote |
|
| 25MG | 274 | Get Quote |
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| 50MG | 408 | Get Quote |
|
| 100MG | 590 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMK-0159
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NoteResearch use only, not for human use.
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Brief DescriptionMK-0159 is an orally available, highly potent CD38 inhibitor with myocardial injury protection for the study of cardiac ischemia and reperfusion injury.
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DescriptionMK-0159 is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart.
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In Vitro——
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In VivoAnimal Model:Cardiac I/R injury miceDosage:30 mg/kg Administration:p.o.Result:Reduced infarct size, and the combination of MK-0159 and NAD+ precursor significantly reduced the infarct size compared to MK-0159 alone.Increased whole heart NAD+ levels and decreased ADPR in the heart.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorCD38
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Research Area——
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Indication——
Chemical Information
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CAS Number2641484-61-7
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Formula Weight400.495
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Molecular FormulaC20H24N4O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (249.69 mM; Ultrasonic )
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SMILESCOCCO[C@H]1CC[C@@H](CC1)NC(=O)c1cc(nc2[nH]ccc12)-c1cncs1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lagu B, et al. Orally Bioavailable Enzymatic Inhibitor of CD38, MK-0159, Protects against Ischemia/Reperfusion Injury in the Murine Heart. J Med Chem. 2022 Jun 28. ?
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