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Thiethylperazine
CAS No. 1420-55-9
Thiethylperazine( —— )
Catalog No. M35603 CAS No. 1420-55-9
Thiethylperazine (Tietilperazina) is an orally available, highly potent D2 receptor and H1 receptor antagonist and selective ABCC1 activator with antimicrobial and antiemetic activity that reduces amyloid β (Aβ) load in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 44 | In Stock |
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| 5MG | 79 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 207 | In Stock |
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| 50MG | 302 | In Stock |
|
| 100MG | 449 | In Stock |
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| 200MG | 648 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameThiethylperazine
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NoteResearch use only, not for human use.
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Brief DescriptionThiethylperazine (Tietilperazina) is an orally available, highly potent D2 receptor and H1 receptor antagonist and selective ABCC1 activator with antimicrobial and antiemetic activity that reduces amyloid β (Aβ) load in mice.
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DescriptionThiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects.
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In VitroThiethylperazine can enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively.
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In VivoThiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) significantly reduces Aβ42 levels in young APP/PS1 mice.Animal Model:Young Aβ precursor protein (APPswe) and mutant presenilin-1 (PS1) (APP/PS1) mice Dosage:3 mg/kg Administration:Intramuscular injection; twice daily; for 30 days Result:Significantly reduced Aβ42 levels in APP/PS1 mice.
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorHistamine Receptor | Dopamine Receptor | Beta Amyloid | ABC
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Research Area——
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Indication——
Chemical Information
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CAS Number1420-55-9
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Formula Weight399.62
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Molecular FormulaC22H29N3S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (250.24 mM; Ultrasonic )
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SMILESCCSc1ccc2Sc3ccccc3N(CCCN3CCN(C)CC3)c2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110(5):497-9.?
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