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LY3372689
CAS No. 2241514-56-5
LY3372689( —— )
Catalog No. M35580 CAS No. 2241514-56-5
LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor targeting tau protein-based disorders, including Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 258 | In Stock |
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| 5MG | 235 | In Stock |
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| 10MG | 353 | In Stock |
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| 25MG | 635 | In Stock |
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| 50MG | 916 | In Stock |
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| 100MG | 1386 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLY3372689
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NoteResearch use only, not for human use.
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Brief DescriptionLY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor targeting tau protein-based disorders, including Alzheimer's disease.
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DescriptionLY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. LY3372689 can be used for tauopathies research, including Alzheimer’s disease.
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In Vitro——
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In VivoLY3372689 shows a dose-dependent change in OGA enzyme occu-pancy (EO) following a single oral dose with a maximum EO of greater than 90% in rat.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMicrotubule Associated
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Research Area——
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Indication——
Chemical Information
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CAS Number2241514-56-5
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Formula Weight383.44
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Molecular FormulaC16H22FN5O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (651.99 mM; Ultrasonic )
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SMILESC[C@H]1C[C@H](CCN1Cc1sc(NC(C)=O)nc1F)OCc1noc(C)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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TRAP-14 amide
TRAP-14 amide
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[Thr46]-Osteocalcin ...
[Thr46]-Osteocalcin (45-49) (human)
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Dieugenol
Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.
