LY3372689( —— )

Catalog No. M35580 CAS No. 2241514-56-5

LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor targeting tau protein-based disorders, including Alzheimer's disease.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	258	In Stock
5MG	235	In Stock
10MG	353	In Stock
25MG	635	In Stock
50MG	916	In Stock
100MG	1386	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

LY3372689
Note

Research use only, not for human use.
Brief Description

LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor targeting tau protein-based disorders, including Alzheimer's disease.
Description

LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. LY3372689 can be used for tauopathies research, including Alzheimer’s disease.
In Vitro

——
In Vivo

LY3372689 shows a dose-dependent change in OGA enzyme occu-pancy (EO) following a single oral dose with a maximum EO of greater than 90% in rat.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Microtubule Associated
Research Area

——
Indication

——

Chemical Information

CAS Number

2241514-56-5
Formula Weight

383.44
Molecular Formula

C16H22FN5O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (651.99 mM; Ultrasonic )
SMILES

C[C@H]1C[C@H](CCN1Cc1sc(NC(C)=O)nc1F)OCc1noc(C)n1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Sergey Shcherbinin, et al. Brain target occupancy of LY3372689, an inhibitor of the O-GlcNAcase (OGA) enzyme: Translation from rat to human. Alzheimer's & Dementia. 07 December 2020 .

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