Cart
sales@molnova.com
LY3372689
CAS No. 2241514-56-5
LY3372689( —— )
Catalog No. M35580 CAS No. 2241514-56-5
LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor targeting tau protein-based disorders, including Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 152 | Get Quote |
|
| 5MG | 235 | Get Quote |
|
| 10MG | 353 | Get Quote |
|
| 25MG | 615 | Get Quote |
|
| 50MG | 906 | Get Quote |
|
| 100MG | 1341 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameLY3372689
-
NoteResearch use only, not for human use.
-
Brief DescriptionLY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor targeting tau protein-based disorders, including Alzheimer's disease.
-
DescriptionLY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. LY3372689 can be used for tauopathies research, including Alzheimer’s disease.
-
In Vitro——
-
In VivoLY3372689 shows a dose-dependent change in OGA enzyme occu-pancy (EO) following a single oral dose with a maximum EO of greater than 90% in rat.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorMicrotubule Associated
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2241514-56-5
-
Formula Weight383.44
-
Molecular FormulaC16H22FN5O3S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (651.99 mM; Ultrasonic )
-
SMILESC[C@H]1C[C@H](CCN1Cc1sc(NC(C)=O)nc1F)OCc1noc(C)n1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Sergey Shcherbinin, et al. Brain target occupancy of LY3372689, an inhibitor of the O-GlcNAcase (OGA) enzyme: Translation from rat to human. Alzheimer's & Dementia. 07 December 2020 .
molnova catalog
related products
-
Steppogenin
Steppogenin exhibits significant tyrosinase inhibition activity, ;it also shows strong mushroom tyrosinase inhibitory activity with IC(50) values lower than 50 microM, more potent than kojic acid (IC(50) = 71.6 microM), a well-known tyrosinase inhibitor.
-
5,7,4-Trihydroxy-8-m...
5,7,4'-Trihydroxy-8-methylflavanone is a natural product.
-
CTX-0124143
CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.
