Guanidinosuccinic acid

Research use only, not for human use.

Guanidinosuccinic acid (GSA) has been identified as a uremic toxin is a nitrogenous metabolite isolated in excess from serum and urine.

Guanidinosuccinic acid (GSA) has been identified as a uremic toxin is a nitrogenous metabolite isolated in excess from serum and urine.

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Guanidinosuccinic acid, a constituent of normal urine, is elevated in the urine and serum of azotemic patients. Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, is administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old. Epileptogenic and toxic properties are assessed and Guanidinosuccinic acid brain levels following i.p. injection ae determined. In adult mice, Guanidinosuccinic acid induces long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD50 (and 95% confidence interval) of 363 (287-458) mg/kg (n=35), and an LD50 of 579 (445-756) mg/kg. The CD50 of Guanidinosuccinic acid corresponded with a brain concentration of 56 nmol/g tissue. Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions, When young mice are i.p. injected with a (for adults) subconvulsive dose of Guanidinosuccinic acid (250 mg/kg), an age-dependent decrease is noted in Guanidinosuccinic acid-induced convulsions and in the resulting brain concentration.

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Others

Other Targets

Others

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6133-30-8

175.14

C5H9N3O4

>98% (HPLC)

DMSO:75 mg/mL (428.23 mM);H2O:6 mg/mL (34.26 mM)

N=C(N)N[C@@H](CC(=O)O)C(=O)O

carbamimidoyl-L-aspartic acid

(-20℃)

With Ice Pack

≥ 2 years