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4-PQBH

CAS No. 2243355-51-1

4-PQBH( —— )

Catalog No. M35557 CAS No. 2243355-51-1

4-PQBH is a potent Nur77-binding agent with antitumour activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    4-PQBH
  • Note
    Research use only, not for human use.
  • Brief Description
    4-PQBH is a potent Nur77-binding agent with antitumour activity.
  • Description
    4-PQBH is a potent Nur77 binder (KD=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2243355-51-1
  • Formula Weight
    367.4
  • Molecular Formula
    C22H17N5O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (68.05 mM; Ultrasonic )
  • SMILES
    O=C(NN=CC=1C=CN=CC1)C2=CC=C(C=C2)NC=3C=CN=C4C=CC=CC43
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Baicun Li, et al. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorg Chem. 2022 Apr;121:105651.?
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