4-PQBH
CAS No. 2243355-51-1
4-PQBH( —— )
Catalog No. M35557 CAS No. 2243355-51-1
4-PQBH is a potent Nur77-binding agent with antitumour activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 105 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name4-PQBH
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NoteResearch use only, not for human use.
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Brief Description4-PQBH is a potent Nur77-binding agent with antitumour activity.
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Description4-PQBH is a potent Nur77 binder (KD=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2243355-51-1
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Formula Weight367.4
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Molecular FormulaC22H17N5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (68.05 mM; Ultrasonic )
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SMILESO=C(NN=CC=1C=CN=CC1)C2=CC=C(C=C2)NC=3C=CN=C4C=CC=CC43
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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γ-2-MSH (41-58), ami...
Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cells. Most of the cells responding to 3-MSH express more than one pituitary hormone mRNA. The effect of 3-MSH is blocked by SHU9119, a MC3R and MC4R antagonist, in only 50% of the responsive cells, suggesting that in half of these cells the mediating receptor is not the MC3R. Low picomolar doses of 3-MSH increase [Ca2+]i in the growth hormone (GH)- and prolactin (PRL)-secreting GH3 cell line.
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Cefazolin
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