Cart
sales@molnova.com
MS023 dihydrochloride
CAS No. 1992047-64-9
MS023 dihydrochloride( —— )
Catalog No. M35545 CAS No. 1992047-64-9
MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
|
| 5MG | 73 | In Stock |
|
| 10MG | 103 | In Stock |
|
| 25MG | 170 | In Stock |
|
| 50MG | 247 | In Stock |
|
| 100MG | 367 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMS023 dihydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionMS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8.
-
DescriptionMS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.
-
In VitroWestern Blot Analysis Cell Line:MCF7 and HEK293 cells Concentration:1.4, 4, 12, 37, 111, 333, and 1000 nM Incubation Time:48 hours for MCF7 cells; 20 hours for HEK293 cells Result:Treatment potently and concentration-dependently reduced cellular levels of H4R3me2a (IC50=9±0.2 nM). Treatment concentration-dependently reduced the H3R2me2a mark (IC50=56±7 nM).
-
In VivoAnimal Model:NOD-scid IL2Rgnull (NSG) mice bearing primary MLL-r ALL cells Dosage:160 mg/kg Administration:Intraperitoneal injection; PKC412 (100 mg/kg, i.g.), MS023 (160 mg/kg, i.p), or a combination for 4 weeks Result:Combinatorial treatment extended survival of leukemic mice relative to single treatments.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorHistone Methyltransferase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1992047-64-9
-
Formula Weight360.32
-
Molecular FormulaC17H27Cl2N3O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : ≥ 150 mg/mL (416.30 mM; )H2O : 33.33 mg/mL (92.50 mM; Ultrasonic)
-
SMILESCl.Cl.CC(C)Oc1ccc(cc1)-c1c[nH]cc1CN(C)CCN
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81.?
molnova catalog
related products
-
Ethyl salicylate
Ethyl salicylate is a natural product.
-
Sodium Thiocyanate
Sodium Thiocyanate one of the main sources of the thiocyanate anion is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals.
-
Agmatine sulfate sal...
Agmatine sulfate is a bioactive metabolite of the arginine amino acid. It exerts modulatory action at multiple molecular targets such as neurotransmitter systems ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.
