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ARN25068

CAS No. 2649882-80-2

ARN25068( —— )

Catalog No. M35549 CAS No. 2649882-80-2

ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ARN25068
  • Note
    Research use only, not for human use.
  • Brief Description
    ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation .
  • Description
    ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation.
  • In Vitro
    ARN25068 reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line. ARN25068 exhibits IC50 values of 4.17 and 2.17 μM for GSK-3β and FYN in enzymatic radiometric assay, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Microtubule Associated | Src | DYRK | GSK-3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2649882-80-2
  • Formula Weight
    362.45
  • Molecular Formula
    C19H18N6S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (551.80 mM; Ultrasonic )
  • SMILES
    N(C1=C2C(=NC(NCC3=CC=CC=C3)=N1)C=CS2)C=4C=C(NN4)C5CC5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054.?
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