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ARN25068
CAS No. 2649882-80-2
ARN25068( —— )
Catalog No. M35549 CAS No. 2649882-80-2
ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 107 | In Stock |
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| 10MG | 180 | In Stock |
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| 25MG | 359 | In Stock |
|
| 50MG | 576 | In Stock |
|
| 100MG | 923 | In Stock |
|
| 200MG | 1237 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameARN25068
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NoteResearch use only, not for human use.
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Brief DescriptionARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation .
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DescriptionARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation.
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In VitroARN25068 reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line. ARN25068 exhibits IC50 values of 4.17 and 2.17 μM for GSK-3β and FYN in enzymatic radiometric assay, respectively.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMicrotubule Associated | Src | DYRK | GSK-3
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Research Area——
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Indication——
Chemical Information
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CAS Number2649882-80-2
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Formula Weight362.45
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Molecular FormulaC19H18N6S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (551.80 mM; Ultrasonic )
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SMILESN(C1=C2C(=NC(NCC3=CC=CC=C3)=N1)C=CS2)C=4C=C(NN4)C5CC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054.?
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