Cart
sales@molnova.com
ARN25068
CAS No. 2649882-80-2
ARN25068( —— )
Catalog No. M35549 CAS No. 2649882-80-2
ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 107 | In Stock |
|
| 10MG | 180 | In Stock |
|
| 25MG | 359 | In Stock |
|
| 50MG | 576 | In Stock |
|
| 100MG | 923 | In Stock |
|
| 200MG | 1237 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameARN25068
-
NoteResearch use only, not for human use.
-
Brief DescriptionARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation .
-
DescriptionARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation.
-
In VitroARN25068 reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line. ARN25068 exhibits IC50 values of 4.17 and 2.17 μM for GSK-3β and FYN in enzymatic radiometric assay, respectively.
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorMicrotubule Associated | Src | DYRK | GSK-3
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2649882-80-2
-
Formula Weight362.45
-
Molecular FormulaC19H18N6S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 200 mg/mL (551.80 mM; Ultrasonic )
-
SMILESN(C1=C2C(=NC(NCC3=CC=CC=C3)=N1)C=CS2)C=4C=C(NN4)C5CC5
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054.?
molnova catalog
related products
-
Pieceid-2-O-gallate
Resveratrol 4'-(6-galloylglucoside) is a natural poduct found in the roots of rhubarb (Rheum palmatum L.).
-
DL5H3
DL5H3 (DL5 H3) is a biochemical.
-
Peptide YY(3-36), PY...
Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion.
