Chitin synthase inhibitor 4

Research use only, not for human use.

Chitin synthase inhibitor 4 is a chitin synthase (CHS) inhibitor with antimicrobial activity.Chitin synthase inhibitor 4 is a CHS-based compound and a candidate fungicide.

Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture.

Chitin synthase inhibitor 4 shows good antifungal activities against V. mali and S. sclerotiorum with EC50 values of 0.71 and 2.47 μg/mL, respectively.Chitin synthase inhibitor 4 (50 μg/mL) displays potency inhibition against V. mali and S. sclerotiorum with inhibition rates of 90.3% and 88.7%, respectivelyChitin synthase inhibitor 4 (1 μg/mL) blocks the hyphae growth, results abnormal growth, with inducing cell content decreasing, cell wall degradation, and plasmolysis.Chitin synthase inhibitor 4 (50 μM; 3 h) exhibits inhibition against chitin synthase and polyoxin D with inhibition rates of 68.08% and 63.84%, respectively.

Chitin synthase inhibitor 4 (50 μg/mL) has considerable curative and protective effects against S. sclerotiorum vivo, and no obvious phytotoxicity .Chitin synthase inhibitor 4 has low acute toxicity, with no carcinogenic and mutagenic toxicity risk.Animal Model:Rat with Salmonella typhimurium Dosage:As Acute Oral Toxicity for Chemicals-Acute Toxic Class Method Administration:Oral gavage Result:Showed acute toxicity of 3.58 as toxicity grading standard, and negative carcinogenic toxicity, negative mutagenic toxicity.

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Microbiology/Virology

Antibiotic

Antibiotic

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2755847-31-3

346.36

C20H15FN4O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (288.72 mM; Ultrasonic )

Fc1c(Oc2ccccc2C#N)ncnc1N1CCCc2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years