Phleomycin( —— )

Catalog No. M23301 CAS No. 11006-33-0

COA

Datasheet

HNMR

HPLC

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Product Name

Phleomycin
Note

Research use only, not for human use.
Brief Description

Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage.
Description

Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage. It is similar to Bleomycin (HY-17565A) which binds and intercalates DNA to damage the integrity of the double helix.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Microbiology/Virology
Target

Antibiotic
Recptor

Antibiotic
Research Area

——
Indication

——

CAS Number

11006-33-0
Formula Weight

1268.29
Molecular Formula

C48H69N17O20S2
Purity

>98% (HPLC)
Solubility

H2O : 100 mg/mL (75.39mM; Need ultrasonic)
SMILES

NC1=NC(C(NCC(N)C(N)=O)CC(N)=N)=NC(C(NC(C(O[C@@]2(OC3[C@H](O)[C@@](O)(C(N)=O)[C@@H](O)C(CO)O3)[C@H](C)[C@@H](O)[C@H](O)[C@H](CO)O2)C4=CNC=N4)C(C(O)C(C)C(NC(C(C)=O)C(NCCC5=NC(C6=NC(C(N)=O)=CS6)CS5)=O)=O)=O)=O)=C1
Chemical Name

——

1.Stokowa-So?tys K, et al. Phleomycin complex - Coordination mode and in vitro cleavage of DNA. J Inorg Biochem. 2019 Jun;195:71-82.

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