FBA-IN-1( —— )

Catalog No. M35457 CAS No. 2605897-57-0

FBA-IN-1 (compound 2a11) is a first-in-class, covalent, and allosteric inhibitor of fructose-1,6-bisphosphate aldolase (FBA) from Candida albicans (CaFBA).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

FBA-IN-1
Note

Research use only, not for human use.
Brief Description

FBA-IN-1 (compound 2a11) is a first-in-class, covalent, and allosteric inhibitor of fructose-1,6-bisphosphate aldolase (FBA) from Candida albicans (CaFBA).
Description

FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candida albicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Microbiology/Virology
Target

Antifungal
Recptor

Antifungal
Research Area

——
Indication

——

Chemical Information

CAS Number

2605897-57-0
Formula Weight

302.23
Molecular Formula

C15H13NOSe
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (330.87 mM; Ultrasonic )
SMILES

O=C1C=2C=CC=CC2[Se]N1C3=CC=C(C=C3)CC
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Wuqiang Wen, et al. Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis. J Med Chem. 2022 Feb 10;65(3):2656-2674.?

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