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CDK9-IN-15
CAS No. 852678-17-2
CDK9-IN-15( —— )
Catalog No. M35446 CAS No. 852678-17-2
CDK9-IN-15 is a potent small molecule CDK9 inhibitor, which can block the phosphorylation of positive transcription elongation factor b (P-TEFb) on the C-terminal region of RNA Poly-II by degradation and inhibition of CDK9, inhibit transcription, and rapidly reduce the level of intracellular mRNA, thereby causing apoptosis of tumor cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
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| 5MG | 39 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 128 | In Stock |
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| 50MG | 187 | In Stock |
|
| 100MG | 269 | In Stock |
|
| 200MG | 377 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCDK9-IN-15
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NoteResearch use only, not for human use.
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Brief DescriptionCDK9-IN-15 is a potent small molecule CDK9 inhibitor, which can block the phosphorylation of positive transcription elongation factor b (P-TEFb) on the C-terminal region of RNA Poly-II by degradation and inhibition of CDK9, inhibit transcription, and rapidly reduce the level of intracellular mRNA, thereby causing apoptosis of tumor cells.
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DescriptionCDK9-IN-15 (compound 50) is a potent CDK9 inhibitor.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number852678-17-2
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Formula Weight293.34
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Molecular FormulaC16H11N3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (426.13 mM; Ultrasonic )
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SMILESOc1cccc2c(Nc3ncnc4sccc34)cccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Van Duyne R, et al. Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription. J Mol Biol. 2013;425(4):812-829.?
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