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AG-024322
CAS No. 837364-57-5
AG-024322( —— )
Catalog No. M33257 CAS No. 837364-57-5
AG-024322 is a potent ATP-competitive inhibitor targeting pan-CDK, effectively inhibiting cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range (1-3 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAG-024322
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NoteResearch use only, not for human use.
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Brief DescriptionAG-024322 is a potent ATP-competitive inhibitor targeting pan-CDK, effectively inhibiting cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range (1-3 nM).
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DescriptionAG-024322 is a potent ATP-competitive pan-CDK inhibitor against cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range. AG-024322 displays broad-spectrum anti-tumor activity and clear target modulation in vivo. AG-024322 induces cell apoptosis.
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In Vitro——
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In VivoAnimal Model:Male and female cynomolgus monkeys Dosage:2, 6, and 10 mg/kg (Toxicity analysis) Administration:Intravenous infusion; 5 days Result:Resulted in dose-dependent pancytic bone marrow hypocellularity and lymphoid depletion in lymph nodes, spleen, and/or thymus at >6 mg/kg.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number837364-57-5
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Formula Weight418.44
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Molecular FormulaC23H20F2N6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (238.98 mM; Ultrasonic )
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SMILESCCNCc1cncc(-c2ccc3[nH]nc(-c4nc5cc(F)cc(F)c5[nH]4)c3c2)c1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Brown AP, et al. Toxicity and toxicokinetics of the cyclin-dependent kinase inhibitor AG-024322 in cynomolgus monkeys following intravenous infusion.Cancer Chemother Pharmacol. 2008 Nov;62(6):1091-101.?
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