NLRP3/AIM2-IN-2( —— )

Catalog No. M35414 CAS No. 791840-86-3

NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent pyroptosis with IC50 of 0.2392 ± 0.0233 μ M.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

NLRP3/AIM2-IN-2
Note

Research use only, not for human use.
Brief Description

NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent pyroptosis with IC50 of 0.2392 ± 0.0233 μ M.
Description

NLRP3/aim2-in-2 (compound 8) is a new potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent cell death. Its < b > IC < sub > 50 < / sub > < / b > value is 0.2392 ± 0.0233 μ M。
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

AIM2
Research Area

——
Indication

——

Chemical Information

CAS Number

791840-86-3
Formula Weight

257.28
Molecular Formula

C15H15NO3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (485.85 mM; Ultrasonic )
SMILES

COc1ccc(CC(=O)Nc2cccc(O)c2)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194.?

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