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NLRP3/AIM2-IN-2

CAS No. 791840-86-3

NLRP3/AIM2-IN-2( —— )

Catalog No. M35414 CAS No. 791840-86-3

NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent pyroptosis with IC50 of 0.2392 ± 0.0233 μ M.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 49 In Stock
5MG 45 In Stock
10MG 76 In Stock
25MG 155 In Stock
50MG 230 In Stock
100MG 346 In Stock
200MG Get Quote In Stock
500MG 808 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    NLRP3/AIM2-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent pyroptosis with IC50 of 0.2392 ± 0.0233 μ M.
  • Description
    NLRP3/aim2-in-2 (compound 8) is a new potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent cell death. Its < b > IC < sub > 50 < / sub > < / b > value is 0.2392 ± 0.0233 μ M。
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    AIM2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    791840-86-3
  • Formula Weight
    257.28
  • Molecular Formula
    C15H15NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (485.85 mM; Ultrasonic )
  • SMILES
    COc1ccc(CC(=O)Nc2cccc(O)c2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194.?
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