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25-Hydroxycholesterol
CAS No. 2140-46-7
25-Hydroxycholesterol( —— )
Catalog No. M19577 CAS No. 2140-46-7
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
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| 10MG | 58 | In Stock |
|
| 25MG | 88 | In Stock |
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| 50MG | 132 | In Stock |
|
| 100MG | 207 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name25-Hydroxycholesterol
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NoteResearch use only, not for human use.
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Brief Description25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs).
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Description25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
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In VitroThe synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorother| HMG-CoA Reductase
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Research Area——
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Indication——
Chemical Information
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CAS Number2140-46-7
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Formula Weight402.65
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Molecular FormulaC27H46O2
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Purity>98% (HPLC)
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SolubilityEthanol: 20 mg/mL;Chloroform: 50 mg/mL
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SMILESC[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.McDonald JG et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.
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