25-Hydroxycholesterol( —— )

Catalog No. M19577 CAS No. 2140-46-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

25-Hydroxycholesterol
Note

Research use only, not for human use.
Brief Description

25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs).
Description

25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
In Vitro

The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems.
In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

other| HMG-CoA Reductase
Research Area

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Indication

——

CAS Number

2140-46-7
Formula Weight

402.65
Molecular Formula

C27H46O2
Purity

>98% (HPLC)
Solubility

Ethanol: 20 mg/mL;Chloroform: 50 mg/mL
SMILES

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Chemical Name

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1.McDonald JG et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.

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