UNC7467

Research use only, not for human use.

UNC7467 is a potent IP6K inhibitor with IC50 values of 4.9 nM for IP6K2, 8.9 nM for IP6K1, and 1320 nM for IP6K6.

UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research.

UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces levels of inositol pyrophosphates. UNC7467 reduces 5-InsP7 levels by 81% and 5-InsP8 levels by 63%.

UNC7467 (5 mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) ameliorated diet induced obesity, insulin resistance, and hepatic steatosis.UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUClast (6054 h?ng/mL for intra venous (i.v.) and 2527 h?ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose.Animal Model:Diet-induced obesity (DIO) mice Dosage:5 mg/kg Administration:Intraperitoneal injection; daily, for 4 weeks Result:Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake.

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Others

Other Targets

Others

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2922283-43-8

315.32

C20H13NO3

>98% (HPLC)

In Vitro:?DMSO : 14.29 mg/mL (45.32 mM; Ultrasonic (<60°C)

O=C(O)C1=CC2=C(C3=CC=C(C4=CC=CC=C4)C=C3)ON=C2C=C1

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(-20℃)

With Ice Pack

≥ 2 years