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SOD1-Derlin-1 inhibitor 56-59
CAS No. 2170170-27-9
SOD1-Derlin-1 inhibitor 56-59( —— )
Catalog No. M35329 CAS No. 2170170-27-9
SOD1-Derlin-1 inhibitor 56-59 is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor 56-59 is potential in Amyotrophic lateral sclerosis (ALS) research.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 44 | In Stock |
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| 5MG | 40 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 126 | In Stock |
|
| 50MG | 182 | In Stock |
|
| 100MG | 274 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSOD1-Derlin-1 inhibitor 56-59
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NoteResearch use only, not for human use.
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Brief DescriptionSOD1-Derlin-1 inhibitor 56-59 is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor 56-59 is potential in Amyotrophic lateral sclerosis (ALS) research.
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DescriptionSOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS).
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In Vitro——
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In VivoAnimal Model:ALS model C57BL/6 mice Dosage:3?mM, flow rate 0.15?μL/h Administration:intracerebroventrical injection Result:Had significantly delayed onset, by a median of 4.5 weeks (14.5% improvement) and prolonged survival, by a median of 5 weeks (14.2% improvement).
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2170170-27-9
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Formula Weight386.47
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Molecular FormulaC22H18N4OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (129.38 mM; Ultrasonic (<60°C)
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SMILESNc1c(sc2nc(ccc12)-c1cccnc1)C(=O)N(CC=C)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668.?
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