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GA-017
CAS No. 2351906-74-4
GA-017( —— )
Catalog No. M35303 CAS No. 2351906-74-4
GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 262 | In Stock |
|
| 5MG | 236 | In Stock |
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| 10MG | 378 | In Stock |
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| 25MG | 615 | In Stock |
|
| 50MG | 918 | In Stock |
|
| 100MG | 1237 | In Stock |
|
| 200MG | 1665 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGA-017
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NoteResearch use only, not for human use.
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Brief DescriptionGA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively.
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DescriptionGA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2351906-74-4
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Formula Weight343.38
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Molecular FormulaC18H21N3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20.83 mg/mL (60.66 mM; Ultrasonic (<80°C)
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SMILESCC\C(=N\NC(=O)NCc1cccc(O)c1)c1ccc(O)c(C)c1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298(4):101779.?
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