(D-Arg1,D-Trp5·7·9,Leu11)-Substance P

3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure.?It reduces cellular ATP creatine and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK) activating PPARγ coactivator 1α (PGC-1α).

KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT.