JAK2-IN-6

Research use only, not for human use.

JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL).

JAK2-IN-6, a multiple-substituted aminothiazole derivative, is a potent and selective JAK2 inhibitor with an IC50 of 22.86 μg/mL. JAK2-IN-6 shows no activity against JAK1 and JAK3. JAK2-IN-6 has anti-proliferative effect against cancer cells.

JAK2-IN-6 (Compound B2; 6.3-50 μg/mL; 48 hours; PC-9, H1975 and PANC-1 cells) treatment exhibits significantly antiproliferative activity against all of these cancer cell lines, with IC50 values of 18.1 μg/mL, 58.3 μg/mL, 40.6 μg/mL against PC-9, H1975 and PANC-1, respectively.JAK2-IN-6 (Compound B2), an intramolecular hydrogen bond is formed, holding the chlorothiophene substituent coplanar with the aminothiazole core. The chlorothiophene moiety is found to be located in the binding pocket adjacent to Val863 and Leu983, and extends towards the Asp994 of activation loop and the Gly993 of glycine-rich loop.:Cell Proliferation Assay Cell Line:PC-9, H1975 and PANC-1 cells Concentration:6.3 μg/mL, 12.5 μg/mL, 25 μg/mL, 50 μg/mL Incubation Time:48 hours Result:Exhibited significantly antiproliferative activity against all of these cancer cell lines.

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Angiogenesis

JAK

JAK

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353512-04-6

335.83

C14H10ClN3OS2

>98% (HPLC)

In Vitro:?DMSO : 60 mg/mL (178.66 mM; ultrasonic and adjust pH to 5 with HCl )

Nc1nc(Nc2ccccc2)sc1C(=O)c1ccc(Cl)s1

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(-20℃)

With Ice Pack

≥ 2 years