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Tyk2-IN-30
CAS No. 1334407-95-2
Tyk2-IN-30( —— )
Catalog No. M11333 CAS No. 1334407-95-2
TYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameTyk2-IN-30
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NoteResearch use only, not for human use.
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Brief DescriptionTYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM.
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DescriptionTYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM, exhibits excellent selectivity (35-fold for JAK1 and 83-fold for JAK3); potently inhibits IL-23 pathway in cells with EC50 of 66 nM, and has good pharmacokinetic properties; demonstrates dose-dependent reduction of IL-17 production in a PK/PD model as well as in an imiquimod-induced psoriasis model.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK
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Research Area——
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Indication——
Chemical Information
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CAS Number1334407-95-2
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Formula Weight396.235
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Molecular FormulaC18H11Cl2N7
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name3,5-dichloro-4-(4-((6-methylpyrimidin-4-yl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)benzonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liang J, et al. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4370-4376.
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