Azido-PEG2-C6-Cl

Research use only, not for human use.

Azido-PEG2-C6-Cl is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Azido-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C6-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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PROTACs

PROTAC

PROTAC Linker

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2568146-55-2

249.74

C10H20ClN3O2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (1001.04 mM; Ultrasonic )

[N-]=[N+]=NCCOCCOCCCCCCCl

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(-20℃)

With Ice Pack

≥ 2 years