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Lenalidomide-OH

CAS No. 1416990-08-3

Lenalidomide-OH( —— )

Catalog No. M23571 CAS No. 1416990-08-3

Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Lenalidomide-OH
  • Note
    Research use only, not for human use.
  • Brief Description
    Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein.
  • Description
    Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620.
  • In Vitro
    Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    Cereblon
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1416990-08-3
  • Formula Weight
    260.25
  • Molecular Formula
    C13H12N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 11 mg/mL (42.27 mM; Need ultrasonic)
  • SMILES
    O=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
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