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Lenalidomide-OH

CAS No. 1416990-08-3

Lenalidomide-OH( —— )

Catalog No. M23571 CAS No. 1416990-08-3

Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 92 In Stock
25MG 37 In Stock
50MG 55 In Stock
100MG 82 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Lenalidomide-OH
  • Note
    Research use only, not for human use.
  • Brief Description
    Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein.
  • Description
    Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620.
  • In Vitro
    Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    Cereblon
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1416990-08-3
  • Formula Weight
    260.25
  • Molecular Formula
    C13H12N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 11 mg/mL (42.27 mM; Need ultrasonic)
  • SMILES
    O=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
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