GNF-8625 monopyridin-N-piperazine hydrochloride
CAS No. 2412055-62-8
GNF-8625 monopyridin-N-piperazine hydrochloride( —— )
Catalog No. M35176 CAS No. 2412055-62-8
GNF-8625 monopyridin-N-piperazine hydrochloride is a tropomyosin receptor kinase (TRK) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 131 | Get Quote |
|
| 5MG | 200 | Get Quote |
|
| 10MG | 321 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGNF-8625 monopyridin-N-piperazine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionGNF-8625 monopyridin-N-piperazine hydrochloride is a tropomyosin receptor kinase (TRK) inhibitor.
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DescriptionGNF-8625 monopyridin-N-piperazine hydrochloride (TRKi-2), a TRK inhibitor, which is from the patent WO 2020038415 A1.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayTyrosine Kinase
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TargetTrk Receptor
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RecptorTrk receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2412055-62-8
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Formula Weight479.98
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Molecular FormulaC25H27ClFN7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 6.67 mg/mL (13.90 mM; Ultrasonic (<60°C)
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SMILESFC=1C=C([C@@H]2N(C3=NN4C(=CN=C4C=C3)C=5N=C(C=CC5)N6CCNCC6)CCC2)C=CC1.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CG 428
CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidomide.
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LOXO-195
LOXO-195 (Selitrectinib;LOXO 195, LOXO195)?is a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.
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GZ389988
GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis; shows similar IC50 values for TrkA, TrkB and TrkC, and the growth factor receptor cFMS (CSF1R).
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