GZ389988( GZ-389988 | GZ 389988 )

Catalog No. M12693 CAS No. 1788906-96-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GZ389988
Note

Research use only, not for human use.
Brief Description

GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis; shows similar IC50 values for TrkA, TrkB and TrkC, and the growth factor receptor cFMS (CSF1R).
Description

GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis; shows similar IC50 values for TrkA, TrkB and TrkC, and the growth factor receptor cFMS (CSF1R), GZ389988 is highly selective against a wide panel of other kinases; GZ389988 can significantly reduces local joint pain, without effect on ipsilateral joint pain; GZ389988 also is efficacious in the PGPS arthritis model, demonstrating a significant improvement of gait analysis scores following painful disease reactivation flares.Other Indication Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

GZ-389988 | GZ 389988
Pathway

Tyrosine Kinase
Target

Trk Receptor
Recptor

Trk Receptor
Research Area

Other Indications
Indication

Other Disease

CAS Number

1788906-96-6
Formula Weight

470.533
Molecular Formula

C26H26N6O3
Purity

>98% (HPLC)
Solubility

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SMILES

NC1=NC2=CC(C3=CN(C)N=C3)=CN=C2N1CC4=CC=C(OCC5=CC=C(OC)C=C5)C(OC)=C4
Chemical Name

3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine