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ARB-272572
CAS No. 2368182-63-0
ARB-272572( —— )
Catalog No. M35168 CAS No. 2368182-63-0
ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 372 | In Stock |
|
| 5MG | 312 | In Stock |
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| 10MG | 449 | In Stock |
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| 25MG | 752 | In Stock |
|
| 50MG | 1070 | In Stock |
|
| 100MG | 1535 | In Stock |
|
| 200MG | 2065 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameARB-272572
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NoteResearch use only, not for human use.
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Brief DescriptionARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.
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DescriptionARB-272572 is a potent small-molecule PD-L1 inhibitor with an IC50 value of 400 pM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetPD-1/PD-L1
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RecptorPD-1/PD-L1
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Research Area——
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Indication——
Chemical Information
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CAS Number2368182-63-0
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Formula Weight568.67
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Molecular FormulaC32H36N6O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (219.81 mM; Ultrasonic )
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SMILESO=C(NC1=CC=CC(C=2C=CC=C(NC(=O)C3=NC=C(C=C3)CNCCO)C2C)=C1C)C4=NC=C(C=C4)CNCCO
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Park JJ, et al. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. 2021 Feb 22;12(1):1222. ?
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