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Autophinib
CAS No. 1644443-47-9
Autophinib( Autophinib )
Catalog No. M12507 CAS No. 1644443-47-9
Autophinib is a novel, potent autophagy inhibitor that inhibits autophagy induced by starvation (IC50=90 nM) or rapamycin (IC50=40 nM) by targeting the lipid kinase VPS34 (IC50=19 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 61 | In Stock |
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| 2MG | 33 | In Stock |
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| 5MG | 53 | In Stock |
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| 10MG | 81 | In Stock |
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| 25MG | 163 | In Stock |
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| 50MG | 222 | In Stock |
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| 100MG | 346 | In Stock |
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| 200MG | 510 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAutophinib
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NoteResearch use only, not for human use.
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Brief DescriptionAutophinib is a novel, potent autophagy inhibitor that inhibits autophagy induced by starvation (IC50=90 nM) or rapamycin (IC50=40 nM) by targeting the lipid kinase VPS34 (IC50=19 nM).
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DescriptionAutophinib is a novel, potent autophagy inhibitor that inhibits autophagy induced by starvation (IC50=90 nM) or rapamycin (IC50=40 nM) by targeting the lipid kinase VPS34 (IC50=19 nM); inhibits LC3 lipidation to form LC3-II, also inhibits p62 degradation dose-dependently in starved MCF7-LC3 cells; an ATP-competitive inhibitor of VPS34 but not other lipid kinases, mTOR and TBK1.
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In Vitro——
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In Vivo——
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SynonymsAutophinib
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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Recptorrapamycin-inducedautophagy|starvation-inducedautophagy|VPS34
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Research Area——
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Indication——
Chemical Information
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CAS Number1644443-47-9
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Formula Weight346.731
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Molecular FormulaC14H11ClN6O3
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Purity>98% (HPLC)
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SolubilityDMSO: 64 mg/mL (184.6 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=[N+](C1=CC=C(OC2=NC(Cl)=CC(NC3=NNC(C)=C3)=N2)C=C1)[O-]
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Chemical Name6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Robke L, et al. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8153-8157.
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