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3-Hydroxykynurenine

CAS No. 484-78-6

3-Hydroxykynurenine( —— )

Catalog No. M34973 CAS No. 484-78-6

3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    3-Hydroxykynurenine
  • Note
    Research use only, not for human use.
  • Brief Description
    3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.
  • Description
    3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis.
  • In Vitro
    Cell Proliferation Assay Cell Line:CD3/CD28 bead-stimulated CD4+?T cells Concentration:0, 20, 40, 60, 80, and 100 μM Incubation Time:72 hours Result:Significantly inhibited CD4+?T-cell proliferation in a dose-dependent manner with an IC50?of approximately 70 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    484-78-6
  • Formula Weight
    224.21
  • Molecular Formula
    C10H12N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?1M HCl : 33.33 mg/mL (148.66 mM; Ultrasonic; (HCL ，pH≈1))
  • SMILES
    NC(CC(=O)c1cccc(O)c1N)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. S Okuda,?et al. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem.?1998 Jan;70(1):299-307.?
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