3-Hydroxykynurenine
CAS No. 484-78-6
3-Hydroxykynurenine( —— )
Catalog No. M34973 CAS No. 484-78-6
3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name3-Hydroxykynurenine
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NoteResearch use only, not for human use.
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Brief Description3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.
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Description3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis.
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In VitroCell Proliferation Assay Cell Line:CD3/CD28 bead-stimulated CD4+?T cells Concentration:0, 20, 40, 60, 80, and 100 μM Incubation Time:72 hours Result:Significantly inhibited CD4+?T-cell proliferation in a dose-dependent manner with an IC50?of approximately 70 μM.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number484-78-6
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Formula Weight224.21
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Molecular FormulaC10H12N2O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?1M HCl : 33.33 mg/mL (148.66 mM; Ultrasonic; (HCL ,pH≈1))
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SMILESNC(CC(=O)c1cccc(O)c1N)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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1,3-BUTANEDIOL
1,3-Butanediol (BD) is a ketogenic substance. Ketone bodies are essential energy substrates in the absence of exogenous nutrients, and more recently.
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Aminomalonic acid
Aminomalonic acid (Ama) was first detected in alkaline hydrolysates of proteins in 1984. Ama has been isolated from proteins of Escherichia coli and human atherosclerotic plaque. The presence of Ama has important biological implications because the malonic acid moiety potentially imparts calcium binding properties to protein.
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R9
(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
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