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Miglustat

CAS No. 72599-27-0

Miglustat( N-Butyldeoxynojirimycin | NB-DNJ | OGT918 )

Catalog No. M24736 CAS No. 72599-27-0

Miglustat is an alkylated product of imino sugar deoxynojirimycin.It is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 93 In Stock
5MG 85 In Stock
10MG 132 In Stock
25MG 245 In Stock
50MG 398 In Stock
100MG 579 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Miglustat
  • Note
    Research use only, not for human use.
  • Brief Description
    Miglustat is an alkylated product of imino sugar deoxynojirimycin.It is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).
  • Description
    Miglustat is an alkylated product of imino sugar deoxynojirimycin.It is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).
  • In Vitro
    ——
  • In Vivo
    Animal Model:NPC1?/? mice Dosage:0.2?mg/kg Administration:Oral administration; once Result:Was able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability.
  • Synonyms
    N-Butyldeoxynojirimycin | NB-DNJ | OGT918
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    72599-27-0
  • Formula Weight
    219.28
  • Molecular Formula
    C10H21NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    O[C@H]1[C@H](O)[C@@H](CO)N(CCCC)C[C@@H]1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Abian, O., et al., Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase. Mol Pharm, 2011. 8(6): p. 2390-7.
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