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AT-121

CAS No. 2099681-31-7

AT-121( —— )

Catalog No. M34966 CAS No. 2099681-31-7

AT-121 is a dual μ-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    AT-121
  • Note
    Research use only, not for human use.
  • Brief Description
    AT-121 is a dual μ-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively).
  • Description
    AT-121 is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects.
  • In Vitro
    ——
  • In Vivo
    AT-121 (0.003-0.03 mg/kg; s.c.) produces potent antinociceptive effect.Animal Model:Adult male and female rhesus monkeysDosage:0.003-0.03 mg/kg Administration:Subcutaneous Result:Produced antinociceptive effects against an acute noxious stimulus, 50 °C water, in a dose-dependent.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    Opioid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2099681-31-7
  • Formula Weight
    462.65
  • Molecular Formula
    C24H38N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C2(C=3C(CN1CCNS(N)(=O)=O)=CC=CC3)CCN(CC2)[C@@H]4CC[C@H]([C@H](C)C)CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ding H, Kiguchi N, Yasuda D, et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med. 2018;10(456):eaar3483. doi:10.1126/scitranslmed.aar3483?
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