Cart
sales@molnova.com
TRPV3 antagonist 74a
CAS No. 1432051-63-2
TRPV3 antagonist 74a( —— )
Catalog No. M34945 CAS No. 1432051-63-2
TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 758 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTRPV3 antagonist 74a
-
NoteResearch use only, not for human use.
-
Brief DescriptionTRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.
-
DescriptionTRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain.
-
In VitroTRPV3 antagonist 74a (100 μΜ; 2300 seconds; keratinocytes) largely attenuates SLIGRL or SLIGKV-induced Ca2+ responses.
-
In VivoTRPV3 antagonist 74a (150 μg; intradermal injection; 30 minutes) decreases the number of scratches significantly..TRPV3 antagonist 74a (10~100 mg/kg; p.o.) dose-dependently attenuates mechanical allodynia induced by von Frey hair stimulation to the ipsilateral (injured) hind paw. TRPV3 antagonist 74a exhibits anti-nociceptive activity in the reserpine model of central pain by increasing muscle pressure threshold.Animal Model:WT mice Dosage:150 μg Administration:Intradermal injection; 30 minutes Result:The number of scratches decreased significantly.
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorTRP/TRPV Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1432051-63-2
-
Formula Weight338.32
-
Molecular FormulaC17H17F3N2O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES[C@H](O)([C@]1(C[C@@](C)(O)C1)C2=CC(C(F)(F)F)=CC=N2)C3=CC=CC=N3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gomtsyan A, et al. Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists. J Med Chem. 2016;59(10):4926-4947.?
molnova catalog
related products
-
A 425619
A 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
-
JT010
JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).
-
TRPM4-IN-1
TRPM4-IN-1 is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.
