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Chlorin E6
CAS No. 19660-77-6
Chlorin E6( —— )
Catalog No. M34843 CAS No. 19660-77-6
Chlorin E6 (CE6) is a second-generation photosensitizer with antitumor activity when used in combination with irradiation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 33 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 42 | In Stock |
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| 50MG | 60 | In Stock |
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| 100MG | 98 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameChlorin E6
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NoteResearch use only, not for human use.
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Brief DescriptionChlorin E6 (CE6) is a second-generation photosensitizer with antitumor activity when used in combination with irradiation.
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DescriptionChlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer.
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In VitroWestern Blot Analysis Cell Line:AsPC-1 and MIA PaCa-2 Cells Concentration:5 μM, 10 μM Incubation Time:3 h Result:Significantly reduced Bcl-2 protein expression while increasing apoptotic molecule expression of Bax.Activated caspase-3 through its cleavage and upregulated the expression of cleaved PARP-1 in a dose-dependent manner.
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In VivoAnimal Model:B16F10 melanoma cells xenograft mouse, PANC02 pancreatic cells xenograft mouse Dosage:2.5 mg/kg Administration:Intravenous injection (i.v.)Result:Significantly reduced tumor volume.
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Synonyms——
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PathwayMicrobiology/Virology
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TargetParasite
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RecptorParasite
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Research Area——
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Indication——
Chemical Information
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CAS Number19660-77-6
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Formula Weight596.67
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Molecular FormulaC34H36N4O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20.83 mg/mL (34.91 mM; Ultrasonic )
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SMILESCCc1c(C)c2cc3[nH]c(cc4nc([C@@H](CCC(O)=O)[C@@H]4C)c(CC(O)=O)c4[nH]c(cc1n2)c(C)c4C(O)=O)c(C)c3C=C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nie M, et al. Photodynamic inactivation mediated by methylene blue or chlorin e6 against Streptococcus mutans biofilm [J]. Photodiagnosis and photodynamic therapy, 2020, 31: 101817.?
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