Cart
sales@molnova.com
Home - Products - Others - Other Targets - 4-hydroperoxy cyclophosphamide

4-hydroperoxy cyclophosphamide

CAS No. 39800-16-3

4-hydroperoxy cyclophosphamide( —— )

Catalog No. M34777 CAS No. 39800-16-3

4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 350 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    4-hydroperoxy cyclophosphamide
  • Note
    Research use only, not for human use.
  • Brief Description
    4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.
  • Description
    4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases.
  • In Vitro
    Western Blot Analysis Cell Line:CTL Concentration:3 μg/mL Incubation Time:24, 48, 72 hResult:Increased the expression of p53 and Bax after 24 h.Apoptosis Analysis Cell Line:Jurkat, CTL Concentration:1 or 3 μg/mL Incubation Time:24 , 48 , 72h Result: Caspase-8 deficiency prevented CD95-mediated death induced by anti-CD95 monoclonal antibody (mAb) APO-1.Overexpression of Bcl-2 inhibited apoptosis. Induced cell death proceeded independently of caspase inhibition.
  • In Vivo
    Animal Model:BALB/c mice Dosage:200 mg/kg Administration:i.p.Result:Exhibited a marked depletion of immature double-positive CD4 t CD8 t thymocytes and mature single-positive CD4+ and CD8+ T cells.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Reactive Oxygen Species | DNA Alkylator/Crosslinker | Apoptosis | Drug Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    39800-16-3
  • Formula Weight
    293.09
  • Molecular Formula
    C7H15Cl2N2O4P
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (170.60 mM; Ultrasonic )
  • SMILES
    O=P1(OCCC(OO)N1)N(CCCl)CCCl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Strauss G, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 2008 Feb;15(2):332-43.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Murine CMV pp 89 (16...

    IE1 peptide refers to an antigenic peptide encoded by the immediate early (IE) gene of mouse cytomegalovirus (mCMV). IE1 peptide is one of the key antigenic peptides expressed during mCMV infection, plays a role in transcriptional activation in the life cycle of mCMV, and is one of the earliest genes expressed in the viral replication cycle. IE1 peptide is an important target for CD8+ T cell response and can be used to study the host immune response to mCMV infection.

  • Fucoidan

    Fucoidan is found in various species of brown seaweed and algaewith anticancer antiviral neuroprotective immune-modulating.

  • Isonemerosin

    Isonemerosin is a natural product for research related to life sciences.

Sign In Join Free