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IL-8 Inhibitor
CAS No. 138559-60-1
IL-8 Inhibitor( ——— )
Catalog No. M41330 CAS No. 138559-60-1
Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameIL-8 Inhibitor
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NoteResearch use only, not for human use.
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Brief DescriptionAntileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.
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DescriptionAntileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.
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In VitroAntileukinate inhibits the binding of human eotaxin to human eosinophils with an IC50 of 8.2 μM.Antileukinate (10-100 μM; 2 hours) significantly suppresses eosinophil chemotaxis to human eotaxin.
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In VivoAntileukinate (52.63 mg/kg; s.c.) protectes mice against acute pancreatitis and associated lung injury.Antileukinate (5mg/kg; s.c.) inhibits the interaction between murine eotaxin and murine eosinophil.Animal Model:Swiss mice (20-25g)Dosage:52.63 mg/kg Administration:Subcutaneous injectionResult:Reduced pancreatic edema induced by Caerulein (50 μg/kg).
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptor———
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Research Area———
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Indication———
Chemical Information
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CAS Number138559-60-1
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Formula Weight1003.2
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Molecular FormulaC45H66N18O7S
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Madhav Bhatia, et al. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regul Pept. 2007 Jan 10;138(1):40-8.?
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