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H-1152 dihydrochloride

CAS No. 871543-07-6

H-1152 dihydrochloride( —— )

Catalog No. M34747 CAS No. 871543-07-6

H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 150 In Stock
5MG 138 In Stock
10MG 227 In Stock
25MG 439 In Stock
50MG 677 In Stock
100MG 918 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    H-1152 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM.
  • Description
    H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    ROCK
  • Recptor
    ROCK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    871543-07-6
  • Formula Weight
    392.34
  • Molecular Formula
    C16H23Cl2N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 35.71 mg/mL (91.02 mM; Ultrasonic)DMSO : 10 mg/mL (25.49 mM; Ultrasonic (<60°C)
  • SMILES
    Cl.Cl.C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(C)c12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. Epub 2005 Sep 12.?
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