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γ-Secretase-IN-1
CAS No. 209986-17-4
γ-Secretase-IN-1( —— )
Catalog No. M34740 CAS No. 209986-17-4
γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 440 | In Stock |
|
| 5MG | 407 | In Stock |
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| 10MG | 653 | In Stock |
|
| 25MG | 1292 | In Stock |
|
| 50MG | 1702 | In Stock |
|
| 100MG | 2306 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Nameγ-Secretase-IN-1
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NoteResearch use only, not for human use.
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Brief Descriptionγ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.
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DescriptionCompound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNeuroscience
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TargetGamma-secretase
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RecptorGamma-secretase | Beta Amyloid
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Research Area——
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Indication——
Chemical Information
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CAS Number209986-17-4
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Formula Weight490.5
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Molecular FormulaC27H24F2N4O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (203.87 mM; Ultrasonic )
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SMILESC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402.?
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