Cart
sales@molnova.com
Minalrestat
CAS No. 129688-50-2
Minalrestat( —— )
Catalog No. M34649 CAS No. 129688-50-2
Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 610 | In Stock |
|
| 10MG | 867 | In Stock |
|
| 25MG | 1302 | In Stock |
|
| 50MG | 1721 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMinalrestat
-
NoteResearch use only, not for human use.
-
Brief DescriptionMinalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.
-
DescriptionMinalrestat (ARI-509) is a potent and orally active aldose reductase inhibitor. Minalrestat can be used in the research of diabetes.
-
In VitroWestern Blot Analysis Cell Line:Primary cultured rat mesangial cells Concentration:100 μM Incubation Time:48 h Result:Increased accumulation of PKC-α and -β2.
-
In VivoAnimal Model:Alloxan (40 mg/kg i.v.)-induced diabetic rats Dosage:10 mg/kg/day Administration:Oral gavage, for 30 days.Result:Restored the decreased microvascular reactivity.
-
Synonyms——
-
PathwayEndocrinology/Hormones
-
TargetReductase
-
RecptorReductase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number129688-50-2
-
Formula Weight449.2
-
Molecular FormulaC19H11BrF2N2O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1C2(C=3C(C(=O)N1CC4=C(F)C=C(Br)C=C4)=CC=C(F)C3)CC(=O)NC2=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Akamine EH, et al. Minalrestat, an aldose reductase inhibitor, corrects the impaired microvascular reactivity in diabetes. J Pharmacol Exp Ther. 2003 Mar;304(3):1236-42. ?
molnova catalog
related products
-
Tolrestat
Tolrestat is a potent inhibitor of aldose reductase (IC50 = 35 nM).
-
Izonsteride
Izonsteride (LY320236) is a selective and potent 5alpha reductase inhibitor with dual action on the type I and type II isoforms of the enzyme.
-
Ranirestat
Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.
