Tolrestat

Research use only, not for human use.

Tolrestat is a potent inhibitor of aldose reductase (IC50 = 35 nM).

Tolrestat is a potent inhibitor of aldose reductase (IC50 = 35 nM).(In Vivo):The estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil, respectively in diabetic rats. Tolrestat inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice. Tolrestat (1.8 mg/kg) causes a reversal of normal RBC sorbitol levels.

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Tolrestat (1.8 mg/kg per day) causes a reversal to normal RBC sorbitol levels diabetic rats. In 21-day diabetic rats, the estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil,respectively. Either tolrestat or sorbinil inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice.

AY-27773

Endocrinology/Hormones

Reductase

SIRT7

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82964-04-3

357.35

C16H14F3NO3S

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (139.92 mM)

COc1ccc2c(cccc2c1C(F)(F)F)C(=S)N(C)CC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years