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Afacifenacin
CAS No. 877606-63-8
Afacifenacin( —— )
Catalog No. M34492 CAS No. 877606-63-8
Afacifenacin (SMP-986) fumarate is an M3 muscarinic receptor-selective antagonist used in the study of ischemic heart disease, urinary incontinence and cystitis and other disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 787 | In Stock |
|
| 10MG | 1074 | In Stock |
|
| 25MG | 1511 | In Stock |
|
| 50MG | 1841 | In Stock |
|
| 100MG | 2325 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAfacifenacin
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NoteResearch use only, not for human use.
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Brief DescriptionAfacifenacin (SMP-986) fumarate is an M3 muscarinic receptor-selective antagonist used in the study of ischemic heart disease, urinary incontinence and cystitis and other disorders.
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DescriptionAfacifenacin (SMP-986) is a potent and orally active muscarinic receptorantagonist. Afacifenacin inhibits the bladder afferent pathway through the sodium-channel blockade, increasing volume, and reducing the frequency of urination and incontinence. Afacifenacin has the potential for the research of overactive bladder (OAB).
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In Vitro——
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In VivoAnimal Model:Male Sprague-Dawley rats (cerebral infarction model)Dosage:0.3, 1, 3 mg/kg Administration:Intragastric administration Result:Significantly increased bladder capaticy and reduced micturition pressure (MP) without affecting residual urinary volume (RUV).
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetAChR
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RecptorAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number877606-63-8
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Formula Weight481.51
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Molecular FormulaC27H26F3N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1N([C@H](C=2C(N1)=CC=CC2)C3=CC=CC=C3)C4CCN(CC5=CC(OC(F)(F)F)=CC=C5)CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yeo EK, et al. New therapies in the treatment of overactive bladder. Expert Opin Emerg Drugs. 2013 Sep;18(3):319-37. ?
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