Afacifenacin( —— )

Catalog No. M34492 CAS No. 877606-63-8

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Product Name

Afacifenacin
Note

Research use only, not for human use.
Brief Description

Afacifenacin (SMP-986) fumarate is an M3 muscarinic receptor-selective antagonist used in the study of ischemic heart disease, urinary incontinence and cystitis and other disorders.
Description

Afacifenacin (SMP-986) is a potent and orally active muscarinic receptorantagonist. Afacifenacin inhibits the bladder afferent pathway through the sodium-channel blockade, increasing volume, and reducing the frequency of urination and incontinence. Afacifenacin has the potential for the research of overactive bladder (OAB).
In Vitro

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In Vivo

Animal Model:Male Sprague-Dawley rats (cerebral infarction model)Dosage:0.3, 1, 3 mg/kg Administration:Intragastric administration Result:Significantly increased bladder capaticy and reduced micturition pressure (MP) without affecting residual urinary volume (RUV).
Synonyms

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Pathway

Cell Cycle/DNA Damage
Target

AChR
Recptor

AChR
Research Area

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Indication

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CAS Number

877606-63-8
Formula Weight

481.51
Molecular Formula

C27H26F3N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1N([C@H](C=2C(N1)=CC=CC2)C3=CC=CC=C3)C4CCN(CC5=CC(OC(F)(F)F)=CC=C5)CC4
Chemical Name

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1. Yeo EK, et al. New therapies in the treatment of overactive bladder. Expert Opin Emerg Drugs. 2013 Sep;18(3):319-37. ?

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