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UR13870
CAS No. 755753-89-0
UR13870( —— )
Catalog No. M34461 CAS No. 755753-89-0
UR-13870 (Org 48762-0) is an orally active and selective inhibitor of p38 mitogen-activated protein kinase (MAPK), which prevents bone damage in collagen-induced arthritis in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 550 | In Stock |
|
| 10MG | 753 | In Stock |
|
| 25MG | 1197 | In Stock |
|
| 50MG | 1516 | In Stock |
|
| 100MG | 1944 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUR13870
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NoteResearch use only, not for human use.
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Brief DescriptionUR-13870 (Org 48762-0) is an orally active and selective inhibitor of p38 mitogen-activated protein kinase (MAPK), which prevents bone damage in collagen-induced arthritis in mice.
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DescriptionOrg 48762-0 is a potent, orally active and selective p38 inhibitor with EC50 of 0.1 μM. Org 48762-0 reduces LPS-induced TNFα release and prevents bone damage in collagen-induced arthritis in mice.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38 MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number755753-89-0
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Formula Weight398.41
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Molecular FormulaC24H16F2N4
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Purity>98% (HPLC)
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Solubility——
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SMILESFC=1C=CC(=CC1)C2=NC3=NN(C=C3C(C=4C=CC(F)=CC4)=C2C=5C=CN=CC5)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. K Mihara, et al. A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha. Br J Pharmacol. 2008 May;154(1):153-64.??
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