Cart
sales@molnova.com
UR13870
CAS No. 755753-89-0
UR13870( —— )
Catalog No. M34461 CAS No. 755753-89-0
UR-13870 (Org 48762-0) is an orally active and selective inhibitor of p38 mitogen-activated protein kinase (MAPK), which prevents bone damage in collagen-induced arthritis in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 347 | Get Quote |
|
| 5MG | 550 | Get Quote |
|
| 10MG | 753 | Get Quote |
|
| 25MG | 1159 | Get Quote |
|
| 50MG | 1500 | Get Quote |
|
| 100MG | 1881 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameUR13870
-
NoteResearch use only, not for human use.
-
Brief DescriptionUR-13870 (Org 48762-0) is an orally active and selective inhibitor of p38 mitogen-activated protein kinase (MAPK), which prevents bone damage in collagen-induced arthritis in mice.
-
DescriptionOrg 48762-0 is a potent, orally active and selective p38 inhibitor with EC50 of 0.1 μM. Org 48762-0 reduces LPS-induced TNFα release and prevents bone damage in collagen-induced arthritis in mice.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMAPK/ERK Signaling
-
Targetp38 MAPK
-
Recptorp38 MAPK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number755753-89-0
-
Formula Weight398.41
-
Molecular FormulaC24H16F2N4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESFC=1C=CC(=CC1)C2=NC3=NN(C=C3C(C=4C=CC(F)=CC4)=C2C=5C=CN=CC5)C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. K Mihara, et al. A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha. Br J Pharmacol. 2008 May;154(1):153-64.??
molnova catalog
related products
-
p38 MAPK-IN-4
p38 MAPK-IN-4 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM for p38α.
-
HS220
HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival.
-
MW181 dihydrochlorid...
MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM.
