UMK57( —— )

Catalog No. M34457 CAS No. 342595-74-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

UMK57
Note

Research use only, not for human use.
Brief Description

UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds, and can improve chromosome separation conservation by disrupting the stability of kinetosomal microtubule (k-MT) attachment during mitosis.
Description

UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Kinesin
Recptor

Kinesin
Research Area

——
Indication

——

CAS Number

342595-74-8
Formula Weight

295.4
Molecular Formula

C17H17N3S
Purity

>98% (HPLC)
Solubility

In Vitro:?Ethanol : 6.67 mg/mL (22.58 mM; Ultrasonic)DMSO : 2 mg/mL (6.77 mM; Ultrasonic (<60°C)
SMILES

CC1=CC=C(C=C1)C1=CSC2=C1C(=NC=N2)N1CCCC1
Chemical Name

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1. Bernardo Orr, et al. Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells. Cell Rep. 2016 Nov 8;17(7):1755-1763.

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