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RL648_81

CAS No. 1919050-87-5

RL648_81( —— )

Catalog No. M34398 CAS No. 1919050-87-5

RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	40	In Stock
5MG	33	In Stock
10MG	61	In Stock
25MG	136	In Stock
50MG	197	In Stock
100MG	277	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

RL648_81
Note

Research use only, not for human use.
Brief Description

RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.
Description

RL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC50 of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has the potential for neurologic disorders associated with neuronal hyperexcitability research.
In Vitro

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In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

Potassium Channel
Research Area

——
Indication

——

Chemical Information

CAS Number

1919050-87-5
Formula Weight

371.33
Molecular Formula

C17H17F4N3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (269.30 mM; Ultrasonic )
SMILES

CCOC(=O)Nc1ccc(NCc2ccc(cc2)C(F)(F)F)c(F)c1N
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Manoj Kumar, et al. Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. Mol Pharmacol. 2016 Jun;89(6):667-77.?

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