Olorofim( —— )

Catalog No. M34247 CAS No. 1928707-56-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Olorofim
Note

Research use only, not for human use.
Brief Description

Olorofim（F-901318）is a novel selective antifungal compound targeting pyrimidine biosynthesis in mycobacteria, with inhibitory effect on Aspergillus fumigatus DHODH (IC50: 44 nM).
Description

Olorofim（F-901318）is a novel selective antifungal compound targeting pyrimidine biosynthesis in mycobacteria, with inhibitory effect on Aspergillus fumigatus DHODH (IC50: 44 nM), but little inhibitory effect on human DHODH (>100 uM).Olorofim has good efficacy against a variety of pathogenic filamentous and dimorphic fungi, such as Penicillium spp, P. dermatitidis spp and Fusarium spp.
In Vitro

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In Vivo

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Synonyms

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Pathway

Metabolic Enzyme/Protease
Target

Dehydrogenase
Recptor

Dehydrogenase | Antifungal
Research Area

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Indication

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CAS Number

1928707-56-5
Formula Weight

498.55
Molecular Formula

C28H27FN6O2
Purity

>98% (HPLC)
Solubility

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SMILES

C(C(NC1=CC=C(C=C1)N2CCN(CC2)C=3N=CC(F)=CN3)=O)(=O)C4=C(C=C(C)N4C)C5=CC=CC=C5
Chemical Name

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