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CPUY192018
CAS No. 1567836-15-0
CPUY192018( —— )
Catalog No. M34215 CAS No. 1567836-15-0
CPUY192018 is an inhibitor of Keap1-Nrf2 protein-protein interactions and shows cytoprotective effects in NCM460 colon cells.CPUY192018 inhibits glycolysis, enhances resistance to oxidative stress, and can be used to study mitochondrial autophagy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 79 | In Stock |
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| 5MG | 117 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 419 | In Stock |
|
| 50MG | 634 | In Stock |
|
| 100MG | 981 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCPUY192018
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NoteResearch use only, not for human use.
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Brief DescriptionCPUY192018 is an inhibitor of Keap1-Nrf2 protein-protein interactions and shows cytoprotective effects in NCM460 colon cells.CPUY192018 inhibits glycolysis, enhances resistance to oxidative stress, and can be used to study mitochondrial autophagy.
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DescriptionCPUY192018 is a potent Keap1-Nrf2-ARE inhibitor with an IC50 of 0.63 μM. CPUY192018 exhibits induction of Nrf2-dependent gene NQO1 at 100 μM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNuclear Receptor/Transcription Factor
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TargetKeap1-Nrf2
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RecptorNrf2
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Research Area——
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Indication——
Chemical Information
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CAS Number1567836-15-0
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Formula Weight614.64
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Molecular FormulaC28H26N2O10S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (406.74 mM; Ultrasonic )
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SMILESO=C(O)CN(C=1C=CC(=C2C=CC=CC21)N(CC(=O)O)S(=O)(=O)C3=CC=C(OC)C=C3)S(=O)(=O)C4=CC=C(OC)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee S, et al. Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2022; 237:114380.?
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