Tigloylgomisin H( —— )

Catalog No. M29235 CAS No. 66069-55-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Tigloylgomisin H
Note

Research use only, not for human use.
Brief Description

Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells.
Description

Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway and can be used in liver cancer prevention studies.(In Vitro):Tigloylgomisin H (TGH) significantly induced QR activity and exhibited a relatively high chemoprevention index (CI) of 10.80 as compared to control. Tigloylgomisin H also induced QR activity in BPrc1 mouse hepatocarcinoma cells as well, which are defective in aryl hydrocarbon nuclear translocator (Arnt). In HepG2 human hepatocarcinoma cells, Tigloylgomisin H significantly activated gene expression mediated by the antioxidant response element (ARE), a key regulatory region in the promoters of detoxification enzymes, through the nuclear accumulation of Nrf2.
In Vitro

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In Vivo

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Synonyms

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Pathway

Nuclear Receptor/Transcription Factor
Target

Keap1-Nrf2
Recptor

Nrf2
Research Area

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Indication

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CAS Number

66069-55-4
Formula Weight

500.59
Molecular Formula

C28H36O8
Purity

>98% (HPLC)
Solubility

——
SMILES

COc1cc2C[C@H](C)[C@@](C)(O)Cc3cc(OC)c(OC)c(OC)c3-c2c(OC(=O)C(\C)=C\C)c1OC
Chemical Name

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