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Home - Products - Immunology/Inflammation - Lipoxygenase - Butibufen

Butibufen

CAS No. 55837-18-8

Butibufen( —— )

Catalog No. M34198 CAS No. 55837-18-8

Butibufen (FF-106) is an orally active non-steroidal anti-inflammatory compound, a potential cyclooxygenase inhibitor with analgesic and antipyretic activity, and inhibits urea synthesis.Butibufen has been used in the study of rheumatic diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Butibufen
  • Note
    Research use only, not for human use.
  • Brief Description
    Butibufen (FF-106) is an orally active non-steroidal anti-inflammatory compound, a potential cyclooxygenase inhibitor with analgesic and antipyretic activity, and inhibits urea synthesis.Butibufen has been used in the study of rheumatic diseases.
  • Description
    Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.
  • In Vitro
    Butibufen (0.1 μM-0.1 M; 60 min) affects cell viability and cell attachment with a high dose.Butibufen (1 μM; 48 h) causes a 100% cell death after 48 h exposure.Butibufen (2 μM-1 mM; 6 h) affects synthesis of albumin in hepatocytes.Butibufen (0.2-0.4 mM; 6 h) impaires gluconeogenesis from lactate and significantly inhibited ureogenesis.Cell Viability Assay Cell Line:Hepatocytes from Sprague-Dawley male rats Concentration:0.1 μM-0.1 M Incubation Time:60 min Result:Showed no cell viability effects under the dose of 200 μM, but dose- and time-dependently affected cell viability with higher concentrations.
  • In Vivo
    Butibufen (50 and 250 mg/kg; p.o. 8 and 3 h before sacrifice) affects acid phosphatase activity.Animal Model:Sprague-Dawley rats Dosage:50 and 250 mg/kg Administration:Oral gavage; 50 and 250 mg/kg; 8 and 3 h before sacrifice Result:Reduced acid phosphatase activity but showed no effect on the stabilization of lysosomal membrane.
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    Lipoxygenase
  • Recptor
    Lipoxygenase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    55837-18-8
  • Formula Weight
    220.31
  • Molecular Formula
    C14H20O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)C(C1=CC=C(C=C1)CC(C)C)CC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Aparicio L. Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. Arch Int Pharmacodyn Ther. 1977 May;227(1):130-41. ?
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