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marmesin

CAS No. 13849-08-6

marmesin( (+)-Marmesin | (S)-Marmesin )

Catalog No. M20394 CAS No. 13849-08-6

Marmesin is a coumarin originally isolated from the mature bark of A. marmelosexhibiting COX-2/5-LOX dual inhibitory activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    marmesin
  • Note
    Research use only, not for human use.
  • Brief Description
    Marmesin is a coumarin originally isolated from the mature bark of A. marmelosexhibiting COX-2/5-LOX dual inhibitory activity.
  • Description
    Marmesin is a coumarin originally isolated from the mature bark of A. marmelosexhibiting COX-2/5-LOX dual inhibitory activity.
  • In Vitro
    S-(+)-Marmesin ((+)-marmesin) shows affinity at the recombinant psoralen synthase, with a Km of 1.5 ± 0.5 μM, exceeding the substrate affinities of other enzymes of the CYP71 subfamily involved in plant secondary metabolism. S-(+)-Marmesin ((+)-marmesin) shows COX-2/5-LOX dual inhibitory activity.
  • In Vivo
    ——
  • Synonyms
    (+)-Marmesin | (S)-Marmesin
  • Pathway
    Immunology/Inflammation
  • Target
    Lipoxygenase
  • Recptor
    5-Lipoxygenase|COX-2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    13849-08-6
  • Formula Weight
    246.26
  • Molecular Formula
    C14H14O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:2 mg/mL (8.12 mM)
  • SMILES
    CC(C)(O)[C@@H]1Cc2cc3ccc(=O)oc3cc2O1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Marmesin is a novel angiogenesis inhibitor: Regulatory effect and molecular mechanism on endothelial cell fate and angiogenesis[J]. Cancer Letters 2015 369(2):323-330.
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