Angstrom6

Research use only, not for human use.

Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and abrogates the downstream effects.

Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.

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Animal Model:C57Bl/6 mice (bearing B16-F10 cells)Dosage:100 mg/kg Administration:S.c.; twice a day for 11 days Result:Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control.

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Metabolic Enzyme/Protease

PAI-1

PAI-1

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220334-14-5

910.97

C39H62N10O15

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (109.77 mM; Ultrasonic )H2O : ≥ 100 mg/mL (109.77 mM)

CC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(N)=O

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(-20℃)

With Ice Pack

≥ 2 years